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4E-BP1 (phospho-Thr37/46) rabbit pAb - Details |
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Alternative Names |
Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) |
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Applications |
WB |
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Recommended Dilutions |
WB 1:1000-2000 |
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Specificity/Sensitivity |
This antibody detects endogenous levels of Human Mouse Rat 4E-BP1 (phospho-Thr37 or 46) |
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Molecular Weight |
18 |
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Immunogen |
Synthesized phosho peptide around human 4E-BP1 (Thr37 and 46) |
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Concentration |
1 mg/ml |
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Form of Antibody |
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
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Storage/Stability |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
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Swiss-Prot No |
Q13541 |
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Gene ID |
1978 |
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Purification |
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
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Background |
eukaryotic translation initiation factor 4E binding protein 1(EIF4EBP1) Homo sapiens This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. |
