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Phospho-4E BP1 (Thr46) Rabbit Monoclonal Antibody - Details |
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Description |
Recombinant Rabbit Monoclonal Antibody |
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Conjugation |
Unconjugated |
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Modification |
Phosphorylated |
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Isotype |
IgG |
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Clonality |
Monoclonal |
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Form |
Liquid |
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Storage |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
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Buffer |
Purified antibody in TBS with 0.05% sodium azide,0.05%protective protein and 50% glycerol. |
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Purification |
Affinity Purification |
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Gene Name |
Phospho-4E BP1 (Thr46) |
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Gene ID |
1978 |
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SwissProt ID |
Q13541 |
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Dilution Ratio |
WB 1:500-1:1000,IHC 1:50-1:100,IP 1:10-1:20 |
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Molecular Weight |
Calculated MW: 13 kDa; Observed MW: 15-20 kDa |
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Alternative Names |
EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I |
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Research Area |
PI3K-Akt signaling pathway,mTOR signaling pathway |
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Background |
Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity. |
