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68kDa Neurofilament Rabbit Monoclonal Antibody - Details |
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Description |
Recombinant rabbit monoclonal antibody |
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Conjugation |
Unconjugated |
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Modification |
Unmodified |
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Isotype |
IgG |
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Clonality |
Monoclonal |
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Form |
Liquid |
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Storage |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
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Buffer |
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% protective protein. Stable for 12 months from date of receipt. |
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Purification |
Affinity purification |
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Gene Name |
68kDa Neurofilament |
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Gene ID |
4747,18039,83613 |
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SwissProt ID |
P08551,P08551,P19527 |
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Dilution Ratio |
WB 1:500-1:2000,IHC 1:500-1:2000,ICC/IF 1:20-1:50,IP 1:20-1:50 |
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Molecular Weight |
Calculated MW:62 kDa; Observed MW:68 kDa |
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Alternative Names |
NFL; NF-L; NF68; CMT1F; CMT2E; PPP1R110 |
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Background |
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Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. |
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