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PP2Cκ Rabbit Polyclonal Antibody - Details |
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Production Name |
PP2Cκ Rabbit Polyclonal Antibody |
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Description |
Rabbit polyclonal Antibody |
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Conjugation |
Unconjugated |
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Modification |
Unmodified |
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Isotype |
IgG |
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Clonality |
Polyclonal |
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Form |
Liquid |
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Storage |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
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Buffer |
Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% New type preservative N. |
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Purification |
Affinity purification |
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Gene Name |
PPM1K |
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Gene ID |
152926 |
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SwissProt ID |
Q8N3J5 |
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Dilution Ratio |
WB 1:500-1:2000,IHC 1:100-1:300,ICC/IF 1:50-1:200,ELISA 1:20000-1:40000 |
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Molecular Weight |
45kDa |
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Alternative Names |
PPM1K; PP2CM; Protein phosphatase 1K; mitochondrial; PP2C domain-containing protein phosphatase 1K; PP2C-like mitochondrial protein; PP2C-type mitochondrial phosphoprotein phosphatase; PTMP; Protein phosphatase 2C isoform kappa; PP2C-kappa |
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Background |
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This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore. catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,caution:Ref.9 has crystallized PPM1K in the presence of magnesium ions. However, PubMed:17336929 reported that no activity toward p-nitrophenylphosphate was seen in the absence of manganese ions and magnesium could not subsitute for manganese.,cofactor:Binds 1 magnesium or manganese ion per subunit.,function:Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.,similarity:Belongs to the PP2C family.,similarity:Contains 1 PP2C-like domain |
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