|
c-Myc Rabbit Monoclonal Antibody - Details |
|
Production Name |
c-Myc Rabbit Monoclonal Antibody |
|
Description |
Recombinant Rabbit Monoclonal Antibody |
|
Conjugation |
Unconjugated |
|
Modification |
Unmodified |
|
Isotype |
IgG, Kappa |
|
Clonality |
Monoclonal |
|
Form |
Liquid |
|
Storage |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
|
Buffer |
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%protective protein |
|
Purification |
Protein A |
|
Gene Name |
MYC |
|
Gene ID |
4609 |
|
SwissProt ID |
P01106 |
|
Dilution Ratio |
WB 1:1000-1:5000,IHC 1:200-1:1000,ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200 |
|
Molecular Weight |
Calculated MW:48kD;Observed MW:60kD |
|
Alternative Names |
Myc proto-oncogene protein;Class E basic helix-loop-helix protein 39;bHLHe39;Proto-oncogene c-Myc;Transcription factor p64 |
|
Research Area |
- |
|
Background |
|
Cell localization:Nucleus.v-myc avian myelocytomatosis viral oncogene homolog(MYC) Homo sapiens The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. |
Reviews
There are no reviews yet.