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ET-1 Rabbit Polyclonal Antibody - Details |
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Production Name |
ET-1 Rabbit Polyclonal Antibody |
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Description |
Rabbit polyclonal Antibody |
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Conjugation |
Unconjugated |
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Modification |
Unmodified |
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Isotype |
IgG |
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Clonality |
Polyclonal |
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Form |
Liquid |
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Storage |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
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Buffer |
Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% New type preservative N. |
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Purification |
Affinity purification |
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Gene Name |
EDN1 |
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Gene ID |
1906 |
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SwissProt ID |
P05305 |
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Dilution Ratio |
WB 1:500-1:2000,IHC 1:100-1:300,ICC/IF 1:50-1:200,ELISA 1:10000-1:20000 |
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Molecular Weight |
25kDa |
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Alternative Names |
EDN1; Endothelin-1; Preproendothelin-1; PPET1 |
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Research Area |
Melanogenesis |
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Background |
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This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],function:Endothelins are endothelium-derived vasoconstrictor peptides.,online information:Endothelin entry,similarity:Belongs to the endothelin/sarafotoxin family.,tissue specificity:Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells. |
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