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HIF-2 alpha Rabbit pAb- Details |
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Alter Name |
bHLHe73;ECYT4;EPAS 1;EPAS1;HIF2A;HLF;MOP 2;PASD2 |
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Swiss-Prot No |
Q99814 |
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Storage/Stability |
Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
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Immunogen |
A synthesized peptide derived from human HIF-2 alpha |
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Purification |
Affinity Chromatography |
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Cellular localization |
Nucleus |
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Antibody type |
Polyclonal antibody |
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Isotype |
Rabbit IgG |
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Molecular Weight |
96kDa |
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Preservative |
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
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Recommended Dilutions |
WB 1:500~1:2000 ICC/IF 1:50~1:200 FC 1:50 |
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Background |
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Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. |
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