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Caveolin-1 Polyclonal Antibody- Details |
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Alter Name |
CAV1; CAV; Caveolin-1 |
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Molecular Weight |
20472Da |
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Gene Name |
CAV1 |
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Dilution |
WB 1:500-2000, IF 1:50-300, IHC 1:50-300 |
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Protein Name |
Caveolin-1 |
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Human Gene Id |
857 |
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Human Swiss Prot No |
Q03135 |
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Mouse Gene Id |
12389 |
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Mouse Swiss Prot No |
P49817 |
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Rat Swiss Prot No |
P41350 |
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Specificity |
Caveolin-1 Polyclonal Antibody detects endogenous levels of Caveolin-1 protein. |
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Formulation |
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
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Concentration |
1 mg/ml |
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Storage Stability |
-20°C/1 year |
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Observed Band(KD) |
25 |
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Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
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Immunogen |
The antiserum was produced against synthesized peptide derived from human Caveolin-1. AA range:129-178 |
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Expression |
Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Expressed in the brain. |
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Background |
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The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1. |
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