Background
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN . Dephosphorylates LYN, and thereby modulates LYN activity.
| Altername | GP180; L CA; CD45 antigen |
| Recommended Dilutions | WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 |
| Purification | Affinity Purification |
| Molecular Weight | Calculated MW: 145 kDa; Observed MW: 145 kDa |
| Immunogen | Synthetic Peptide of CD45 |
| Product Type | Primary Antibody |
| Clone Number | 8C1-9B8-2H1 |
| Isotype | IgG1 |
| Gene ID | 19264 |
| Gene Name | Ptprc |
| Swiss-Prot No | P06800 |
| Storage/Stability | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Form of Antibody | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Shipping & Stablity | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. |
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