Background
Act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of ERK2 requires its phosphorylation by upstream kinases. ERK2 is located in the cytoplasm of resting cells and translocates into the nucleus upon extracellular stimuli by active transport of a dimer. ERK2 is essential for placental development and ERK2 in the trophoblast compartment may be indispensable for the vascularization of the labyrinth.
| Altername | ERK; p38; p40; p41; ERT1; MAPK2; PRKM1; P42MAPK; p41mapk; MAPK |
| Recommended Dilutions | WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/20 |
| Purification | Affinity Purified |
| Isotype | IgG |
| Molecular Weight | Calculated MW: 41 kDa; Observed MW: 41 kDa |
| Immunogen | A synthetic peptide of human ERK2 |
| Gene ID | 5594 |
| Gene Name | MAPK1 |
| Clone Number | R07-1A9 |
| Antibody type | Monoclonal Antibody |
| Swiss-Prot No | P28482 |
| Storage/Stability | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Form of Antibody | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
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