Background
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.
| Altername | STAT6B; STAT6C; D12S1644; IL-4-STAT |
| Recommended Dilutions | WB: 1:1000 IHC: 1:50-1:200 ICC/IF: 1:100 FC: 1:20 IP: 1:20 |
| Purification | Affinity Purification |
| Specificity | IgG |
| Molecular Weight | 110 kDa |
| Immunogen | A synthetic peptide of human STAT6 |
| Conjugate | Unconjugated |
| Modification | Unmodification |
| Formulation | Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| Storage/Stability | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
Reviews
There are no reviews yet.