| Alternative Names | Activating Transcription factor 6; ATF6A |
| Description | Recombinant Rabbit Monoclonal Antibody |
| Clonality | Monoclonal |
| Form | Liquid |
| Conjugation | Unconjugated |
| Modification | Unmodified |
| Isotype | IgG |
| Buffer | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein |
| Purification | Affinity Chromatography |
| Gene Name | ATF6 |
| Gene ID | 22926 |
| SwissProt ID | P18850 |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Dilution Ratio | WB 1:500-1:1000,IHC 1:50-1:100,IP 1:20-1:50 |
| Molecular Weight | Calculated MW: 75 kDa; Observed MW: 90-100 kDa |
Background
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.
Research Area
Epigenetics and Nuclear Signaling
Reviews
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