| Altername | EIF2AK3; PEK; PERK; Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK |
| Recommended Dilutions | WB: 1/500-1/1000 |
| Product Type | Primary Antibody |
| Immunogen | Recombinant protein of human PERK |
| Clone Number | R09-1F9 |
| Isotype | IgG |
| Purification | Affinity Purified |
| Gene Name | EIF2AK3 |
| Antibody type | Monoclonal Antibody |
| Gene ID | 9451 |
| Molecular Weight | Calculated MW: 125 kDa; Observed MW: 140 kDa |
| Swiss-Prot No | Q9NZJ5 |
| Storage/Stability | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Form of Antibody | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
Background
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on ‘Ser-52’ during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.
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