| Description | Rabbit Monoclonal antibody |
| Alternative Names | G3PD; GAPD; HEL-S-162eP |
| Gene Name | GAPDH |
| Form | Liquid |
| Isotype | IgG |
| Reactivity | Human, Mouse, Rat, Monkey, Rabbit, Chicken, Zebrafish, Rabbit, Xenopus tropicalis, Chinese hamster, E. Escherichia coli |
| Clonality | Monoclonal Antibody |
| Conjugation | Unconjugated |
| Modification | Unmodified |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Purification | Affinity Purification |
| Gene ID | 14433 |
| SwissProt ID | P16858 |
| Dilution Ratio | WB: 1:1000-1:5000 IHC-P: 1:200-1:2000 ICC/IF: 1:200-1:500 FC: 1:100-1:200 IP: 1:50 |
| Molecular Weight | Calculated MW:36 kDa; Observed MW:36 kDa |
Background
This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein was originally identified as a key glycolytic enzyme that converts D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Subsequent studies have assigned a variety of additional functions to the protein including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Alternative splicing results in multiple transcript variants. Many pseudogenes similar to this locus are found throughout the mouse genome.