|
53BP1 Rabbit Monoclonal Antibody - Summary |
|
Description |
Rabbit Monoclonal Antibody |
|
Alternative Names |
TP53; p202; 53BP1; TDRD30; p53BP1 |
|
Gene Name |
53BP1 |
|
Isotype |
IgG |
|
Form |
Liquid |
|
Clonality |
Monoclonal Antibody |
|
Conjugation |
Unconjugated |
|
Modification |
Unmodified |
|
Storage |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
|
Purification |
Affinity Purification |
|
Gene ID |
7158 |
|
SwissProt ID |
Q12888 |
|
Dilution Ratio |
WB: 1:1000 IHC: 1:100-1:200 ICC/IF: 1:100-1:200 FC: 1:20 |
|
Molecular Weight |
Calculated MW:214 kDa; Observed MW:450 kDa |
|
Background |
|
This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms |
Reviews
There are no reviews yet.