This column represents the standard format for routine nucleic acid purification in laboratory workflows. It is typically used for genomic DNA extraction, RNA purification, and cleanup steps following enzymatic reactions.

The membrane structure is optimized for consistent binding performance across a wide range of sample types, making it suitable for general-purpose use without the need for workflow adjustments.

Based on the negatively charged DNA skeleton, it has a high affinity for positively charged glass fibers. In high salt and ethanol solutions, DNA/RNA binds to glass fiber and interacts with hydrophilic matrix on silica through hydrogen bond. DNA/RNA is tightly bound. All pollutants can be removed by washing solution. At high salt concentration, nucleic acids selectively bind to silicagel membrane, while other pollutants, mainly proteins, are removed by membrane washing.