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SOD2/MnSOD Antibody |
|
Description |
Rabbit Polyclonal Antibody To SOD2/MnSOD |
|
Mol.Wt |
22kDa(Observed); 25kD(Calculated). |
|
Uniprot |
P04179 |
|
Application |
IHC 1:50-1:200, WB 1:500-1:2000 |
|
Clonality |
Polyclonal |
|
Specificity |
SOD2/MnSOD Antibody detects endogenous levels of total SOD2/MnSOD. |
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Conjugate |
Unconjugated. |
|
Purification |
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin. |
|
Storage |
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt. |
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Alternative Name |
Indophenoloxidase B; IPO B; IPOB; Manganese containing superoxide dismutase; Manganese SOD; Manganese superoxide dismutase; Mangano superoxide dismutase; Mn SOD; Mn superoxide dismutase; MNSOD; MVCD6; SOD 2; SOD2; SODM_HUMAN; Superoxide dismutase [Mn] mitochondrial; Superoxide dismutase [Mn], mitochondrial; Superoxide dismutase 2 mitochondrial |
|
Immunogen |
A synthesized peptide derived from human SOD2/MnSOD, corresponding to a region within the internal amino acids. |
|
Gene(ID) |
SOD2(6648) |
|
Uniprot |
P04179(SODM_HUMAN) |
|
Family & Domains |
Belongs to the iron/manganese superoxide dismutase family. |
|
Subcellular Location |
Mitochondrion matrix. |
|
Function |
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. |
|
PTMs |
Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity. Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity). Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability. |
