|
Rabbit Anti-Claudin 18.2 Antibody |
|
Clonality |
Monoclonal |
|
concentration |
1mg/ml |
|
Alternative News |
Claudin-18; CLD18_HUMAN; CLDN18; SFTA5; SFTPJ; UNQ778/PRO1572. |
|
Research Area |
Cell biology Signal transduction Transporter Cell adhesion molecule endothelial cells Transmembrane protein |
|
Clone NO |
R7G12 |
|
Applications |
IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 (Paraffin sections need antigen repair） |
|
Molecular weight |
28kDa |
|
Cellular localization |
The cell membrane |
|
Form |
Liquid |
|
Concentration |
1mg/ml |
|
immunogen |
KLH conjugated synthetic peptide derived from human Claudin 18 |
|
Lsotype |
IgG |
|
Purification |
affinity purified by Protein A |
|
Buffer Solution |
Human,Mouse,Rat1M TBS(pH7.4) with 1% BSA, Human,Mouse,Rat3% Proclin300 and 50% Glycerol. |
|
Storage |
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
|
Gene ID |
51208 |
|
SWISS ID |
P56856 |
|
Background |
The Claudin superfamily consists of many structurally related proteins in humans (1). These proteins are important structural and functional components of tight junctions in paracellular transport (1,2). Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues (1). Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and Junction adhesion molecule (3). Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands (4). Emerging evidence suggests that the Claudin family of proteins regulates transport through tight junctions via differential discrimination for solute size and charge (5).Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions |
