Description

Dextran sulfate sodium salt, or DSS, is a synthetic sulfated branched polysaccharide derivative of dextran that has multiple uses in biomedical and clinical research (see table below). One important property of DSS is to trigger colitis in mice and rats by binding to medium-chain-length fatty acids in the colon and inducing intestinal inflammation.

Application Notes

Dextran sulfate sodium (DSS) is one of the most common and effective compounds used for inducing ulcerative colitis in animals. The DSS colitis model has also been used extensively to study colon cancer developing in relation to colonic inflammation, such as that occurring in patients with long-standing ulcerative colitis.

Biostring Inc, offers the gold standard of colitis model creation reagents – colitis grade dextran sulfate sodium salt (36,000-50,000) and colonic carcinogen azoxymethane (AOM).

Because of its high efficacy, DSS is one of the most widely used DSS products in the scientific literature.

Usage Statement

Unless specified otherwise, Biostring Inc, products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Acute/ Chronic Ulcerative Colitis Model Induction, Chronic Colitis Associated Colon Cancer Model Induction

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